Two mutated genes, your signs and symptoms will be moderate to severe. This condition is called thalassemia minor or beta-thalassemia. One mutated gene, you'll have mild signs and symptoms.Two genes are involved in making the beta hemoglobin chain. In rare cases, a child born with this condition can be treated with transfusions and a stem cell transplant. Babies born with this condition often die shortly after birth or require lifelong transfusion therapy. Inheriting four mutated genes is rare and usually results in stillbirth. Three mutated genes, your signs and symptoms will be moderate to severe.This condition might be called alpha-thalassemia trait. Two mutated genes, your thalassemia signs and symptoms will be mild.But you are a carrier of the disease and can pass it on to your children. One mutated gene, you'll have no signs or symptoms of thalassemia.Alpha-thalassemiaįour genes are involved in making the alpha hemoglobin chain. In beta-thalassemia, the severity of thalassemia you have depends on which part of the hemoglobin molecule is affected. The more mutated genes, the more severe your thalassemia. In alpha-thalassemia, the severity of thalassemia you have depends on the number of gene mutations you inherit from your parents. In thalassemia, the production of either the alpha or beta chains are reduced, resulting in either alpha-thalassemia or beta-thalassemia. Hemoglobin molecules are made of chains called alpha and beta chains that can be affected by mutations. The mutations associated with thalassemia are passed from parents to children. Thalassemia is caused by mutations in the DNA of cells that make hemoglobin - the substance in red blood cells that carries oxygen throughout your body.
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